Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296939 | 0.90 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL1972315 | 0.89 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL3333281 | 0.88 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL5866394 | 0.88 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL2857988 | 0.87 | HTT (0.62) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL2729787 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL5866443 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL5866379 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL1307173 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 | |
| SCHEMBL5866409 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AKDM4ECHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076983-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | GILEAD SCIENCES, INC. (US) | 2023-05-04 | — | — | WO | disclosed |