Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1341743 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTTP53TDP1NPC1 | |
| SCHEMBL1340974 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTTP53TDP1GAA | |
| SCHEMBL1341508 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTTP53TDP1GAA | |
| SCHEMBL1346351 | 0.75 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTTP53TDP1GAA | |
| SCHEMBL1340947 | 0.75 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTTDP1GAA | |
| SCHEMBL2651360 | 0.74 | SMN1; SMN2 (0.35) | SMN1; SMN2 | |
| SCHEMBL1341528 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTTP53TDP1NPC1 | |
| SCHEMBL2652027 | 0.73 | OGA (0.44) | SMN1; SMN2 | |
| SCHEMBL1340981 | 0.72 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTTDP1GAACCNE2 | |
| SCHEMBL1340483 | 0.72 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |