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SCHEMBL2651292

SCHEMBL2651292

CC(=O)N1CCN(Cc2cnc(NC(=O)Nc3ccc(C)cc3N3CCCCC3)s2)CC1.Cc1ccc(NC(=O)Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)s2)c(N2CCCCC2)c1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GCK P35557 2/20 0.46
▸ OGA O60502 12/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.39
▸ KCNH2 Q12809 1/20 0.39
▸ POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1343325 0.96 SMN1; SMN2 (0.47) GCKOGASMN1; SMN2KCNH2POLB
SCHEMBL1342754 0.94 OGA (0.51) GCKOGASMN1; SMN2POLB
SCHEMBL1343375 0.88 SMN1; SMN2 (0.56) OGASMN1; SMN2POLB
SCHEMBL2651294 0.87 GCK (0.38) GCKOGASMN1; SMN2TDP1POLB
SCHEMBL1343032 0.86 SMN1; SMN2 (0.50) GCKOGASMN1; SMN2KCNH2POLB
SCHEMBL1343227 0.84 SMN1; SMN2 (0.48) OGASMN1; SMN2POLB
SCHEMBL1343127 0.84 SMN1; SMN2 (0.50) OGASMN1; SMN2POLB
SCHEMBL1341711 0.83 SMN1; SMN2 (0.49) OGASMN1; SMN2POLB
SCHEMBL2650754 0.83 SMN1; SMN2 (0.52) OGASMN1; SMN2POLB
SCHEMBL1342740 0.81 POLB (0.43) SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1531815-A1 GLUCOKINASE ACTIVATORS NOVO NORDISK A/S (DK) 2005-05-25 — — EP disclosed
WO-2004002481-A1 ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS NOVO NORDISK A/S (DK) 2004-01-08 — — WO disclosed