Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343346 | 0.91 | TP53 (0.43) | TP53GAAPOLBITGB1ITGA4 | |
| SCHEMBL2651483 | 0.91 | POLB (0.37) | TP53GAAPOLBTDP1SMN1; SMN2 | |
| SCHEMBL1342589 | 0.90 | TP53 (0.43) | TP53GAAPOLBGCKITGB1 | |
| SCHEMBL1341673 | 0.88 | TP53 (0.47) | TP53GAAPOLBGCKSMN1; SMN2 | |
| SCHEMBL1342615 | 0.88 | TP53 (0.48) | TP53GAAPOLBTDP1SMN1; SMN2 | |
| SCHEMBL1341845 | 0.84 | PTGDR2 (0.46) | TP53GAAPOLBPTGDR2SMN1; SMN2 | |
| SCHEMBL6697191 | 0.84 | TP53 (0.44) | TP53GAAPOLBTDP1PTGDR2 | |
| SCHEMBL1343016 | 0.81 | TP53 (0.47) | TP53GAASMN1; SMN2MAPTLMNA | |
| SCHEMBL1343035 | 0.80 | TP53 (0.46) | TP53GAASMN1; SMN2MAPTLMNA | |
| SCHEMBL1340636 | 0.80 | TP53 (0.45) | TP53GAAITGB1ITGA4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |