Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 7/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651685 | 0.95 | MAPT (0.38) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1341125 | 0.95 | GAA (0.34) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1342130 | 0.95 | MAPT (0.38) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2650681 | 0.87 | MAPT (0.41) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1342857 | 0.85 | ABCC1 (0.33) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1341843 | 0.85 | TP53 (0.35) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1342581 | 0.85 | GAA (0.34) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2649399 | 0.85 | MAPT (0.38) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1343087 | 0.84 | GAA (0.33) | MAPTMEN1KMT2AGAATP53 | |
| SCHEMBL1341144 | 0.84 | MAPT (0.37) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |