Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.56 |
| ▸ | GSK3B | P49841 | 5/20 | 0.56 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CDK7 | P50613 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.45 |
| ▸ | CCNH | P51946 | 3/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18122643 | 0.89 | CDK2 (0.59) | CDK2GSK3BCDK9MAPKAPK2CSNK2B | |
| SCHEMBL20549682 | 0.89 | CDK2 (0.59) | CDK2GSK3BCDK9MAPKAPK2CSNK2B | |
| SCHEMBL20549680 | 0.89 | CDK2 (0.59) | CDK2GSK3BCDK9MAPKAPK2CSNK2B | |
| SCHEMBL21473082 | 0.89 | CDK2 (0.59) | CDK2GSK3BCDK9MAPKAPK2CSNK2B | |
| SCHEMBL33377999 | 0.82 | CSNK2B (0.60) | CDK2GSK3BCDK9CDK7CCNE1 | |
| SCHEMBL18122642 | 0.80 | CDK2 (0.42) | CDK2GSK3BCDK9CDK7CCNE1 | |
| SCHEMBL14427397 | 0.79 | CDK2 (0.84) | CDK2GSK3BCDK9CCNE1CDK1 | |
| SCHEMBL21741557 | 0.78 | CDK2 (0.63) | CDK2GSK3BCDK9CDK7CCNE1 | |
| SCHEMBL20286069 | 0.75 | CDK2 (0.53) | CDK2GSK3BCDK9CDK7CCNH | |
| SCHEMBL20549736 | 0.74 | CDK2 (0.48) | CDK2GSK3BMAPKAPK2CSNK2BCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3273966-B1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | DANA FARBER CANCER INST INC (US) | 2023-05-03 | — | — | EP | disclosed |