Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BUB1B | O60566 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264498 | 0.99 | BRD4 (0.48) | BRD4JAK2JAK3BUB1BRET | |
| SCHEMBL264535 | 0.93 | KCNA5 (0.50) | BRD4JAK2JAK3BUB1BRET | |
| SCHEMBL263109 | 0.89 | JAK2 (0.51) | BRD4JAK2JAK3BUB1BRET | |
| SCHEMBL265824 | 0.88 | BRD4 (0.46) | BRD4JAK2JAK3BUB1BRET | |
| Hydrochloric Acid SCHEMBL263808 | 0.85 | BRD4 (0.49) | BRD4JAK2JAK3BUB1BRET | |
| SCHEMBL263688 | 0.85 | JAK2 (0.48) | BRD4JAK2JAK3JAK1FLT3 | |
| SCHEMBL266184 | 0.83 | BRD4 (0.47) | BRD4JAK2JAK3BUB1BRET | |
| SCHEMBL265875 | 0.80 | BRD4 (0.63) | BRD4ALKALDH1A1MAPT | |
| SCHEMBL270132 | 0.78 | BRD4 (0.77) | BRD4JAK2JAK3BUB1BRET | |
| SCHEMBL270719 | 0.78 | BRD4 (0.76) | BRD4JAK2JAK3BUB1BRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |