SCHEMBL2652223

CC(C)(C)c1ccc(C(Oc2ccc(C(=O)NCCC(=O)O)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)nc2)cc1.COC(=O)CCNC(=O)c1ccc(OC(c2ccc(C(C)(C)C)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)nc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	GCGR	P47871	18/20	0.51

▸	ADCY6	O43306	2/20	0.51

▸	ADCY3	O60266	2/20	0.51

▸	ADCY9	O60503	2/20	0.51

▸	ADCY5	O95622	2/20	0.51

▸	ADCY8	P40145	2/20	0.51

▸	ADCY7	P51828	2/20	0.51

▸	ADCY2	Q08462	2/20	0.51

▸	ADCY1	Q08828	2/20	0.51

▸	ADCY4	Q8NFM4	2/20	0.51

▸	GCG	P01275	4/20	0.49

▸	GLP1R	P43220	1/20	0.45

▸	GIPR	P48546	1/20	0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2270383	0.97	GCGR (0.46)	GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL2270381	0.97	GCGR (0.46)	GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL2269730	0.96	GCGR (0.54)	GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL2269725	0.96	GCGR (0.54)	GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL2653064	0.89	GCGR (0.53)	GCGRGCGGLP1RGIPR
SCHEMBL2272360	0.84	GCG (0.57)	GCGRGCGGLP1RGIPR
SCHEMBL2272362	0.84	GCG (0.57)	GCGRGCGGLP1RGIPR
SCHEMBL2271957	0.83	GCGR (0.56)	GCGRGCGGLP1RGIPR
SCHEMBL2271843	0.83	GCG (0.56)	GCGRGCGGLP1RGIPR
SCHEMBL2271848	0.83	GCG (0.56)	GCGRGCGGLP1RGIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1758859-A1	GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES	ELI LILLY AND COMPANY (US)	2007-03-07	—	—	EP	disclosed
WO-2005118542-A1	GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES	ELI LILLY AND COMPANY (US)	2005-12-15	—	—	WO	disclosed