Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | GCGR | P47871 | 4/20 | 0.50 |
| ▸ | GIPR | P48546 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | PPARD | Q03181 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | RHOC | P08134 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652593 | 0.94 | MEN1 (0.57) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2653326 | 0.94 | MEN1 (0.57) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2651906 | 0.94 | MEN1 (0.56) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2655721 | 0.94 | MEN1 (0.56) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2652886 | 0.93 | MEN1 (0.55) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2654122 | 0.93 | MEN1 (0.55) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2653574 | 0.93 | MEN1 (0.55) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2652235 | 0.93 | MEN1 (0.55) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2654985 | 0.93 | MEN1 (0.55) | MEN1KMT2AFFAR1FFAR4GCGR | |
| SCHEMBL2653662 | 0.93 | MEN1 (0.55) | MEN1KMT2AFFAR1FFAR4GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |