Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.75 |
| ▸ | IRAK2 | O43187 | 1/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.60 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26528553 | 0.91 | IRAK4 (0.73) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21678424 | 0.87 | IRAK4 (0.63) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21678421 | 0.87 | IRAK4 (0.63) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21105711 | 0.86 | IRAK4 (1.00) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21106696 | 0.83 | IRAK4 (1.00) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21705145 | 0.82 | IRAK4 (0.67) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21678524 | 0.82 | IRAK4 (0.67) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL27378229 | 0.81 | IRAK4 (0.67) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21704990 | 0.81 | IRAK4 (0.64) | IRAK4IRAK2CLK1CLK2IRAK1 | |
| SCHEMBL21106698 | 0.80 | IRAK4 (1.00) | IRAK4IRAK2CLK1CLK2IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024092011-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-05-02 | — | — | WO | disclosed |
| WO-2023192586-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |