Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 5/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653733 | 0.98 | MAOB (0.56) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL2652794 | 0.98 | MAOB (0.56) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL2653224 | 0.94 | MAOB (0.59) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL2957360 | 0.94 | HDAC1 (0.57) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL23176839 | 0.92 | HDAC1 (0.56) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL4089161 | 0.92 | HDAC1 (0.56) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL1047276 | 0.92 | HDAC1 (0.56) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL1079525 | 0.92 | HDAC1 (0.56) | MAOBHDAC1HDAC8FDFT1P2RY14 | |
| SCHEMBL81840 | 0.88 | TAAR1 (0.57) | MAOBHDAC1HDAC8FDFT1TAAR1 | |
| SCHEMBL2272957 | 0.86 | MAOB (0.63) | MAOBHDAC1HDAC8FDFT1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |