Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Omeprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 6/20 | 0.59 |
| ▸ | ATP4B known ✓ | P51164 | 6/20 | 0.59 |
| ▸ | BRS3 | P32247 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.59 |
| ▸ | ATP1A1 | P05023 | 5/20 | 0.59 |
| ▸ | ATP1B1 | P05026 | 5/20 | 0.59 |
| ▸ | ATP1A3 | P13637 | 5/20 | 0.59 |
| ▸ | ATP1B2 | P14415 | 5/20 | 0.59 |
| ▸ | ATP1A2 | P50993 | 5/20 | 0.59 |
| ▸ | ATP1B3 | P54709 | 5/20 | 0.59 |
| ▸ | FXYD2 | P54710 | 5/20 | 0.59 |
| ▸ | ATP1A4 | Q13733 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.59 |
| ▸ | WDR5 | P61964 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.59 |
| ▸ | ENGASE | Q8NFI3 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Omeprazole SCHEMBL7867626 | 1.00 | BRS3 (0.61) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL6320170 | 1.00 | BRS3 (0.61) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL5803198 | 0.99 | BRS3 (0.60) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Esomeprazole SCHEMBL30426884 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL140006 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL29772327 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL1192 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Esomeprazole SCHEMBL29691369 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Esomeprazole SCHEMBL19535 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL29360040 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1262 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119735576-A | Preparation method of omeprazole sodium hemihydrate microcrystal | 海南灵康制药有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119679816-A | Muscle-relaxing antagonistic drug for reversing benzylisoquinoline muscle-relaxing drug | 杭州奥默医药股份有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-115919851-B | Omeprazole sodium freeze-dried powder composition for injection and application thereof | 山东北大高科华泰制药有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-222041156-U | Storage and shipment box for omeprazole sodium syringe | 东莞市康源药业有限公司 | 2024-11-22 | — | — | CN | claimed |
| CN-118090947-B | Quality detection technology and application of omeprazole magnesium compound chewable tablet | 青岛国信制药有限公司 | 2024-11-08 | — | — | CN | claimed |
| CN-118090947-A | Quality detection technology and application of omeprazole magnesium compound chewable tablet | 正大制药（青岛）有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-118067887-A | Method for detecting omeprazole sodium related substances for injection | 青海晨菲制药有限公司 | 2024-05-24 | — | — | CN | claimed |
| US-20240041773-A1 | POWDER MIXING DEVICE, AND USES THEREOF | UNIV CONNECTICUT (US) | 2024-02-08 | — | — | US | claimed |
| CN-115645373-B | Preparation method of omeprazole sodium tablet | 山东理工职业学院 | 2024-01-30 | — | — | CN | claimed |
| CN-115227656-B | Preparation method of omeprazole sodium for injection | 海南锦瑞制药有限公司 | 2023-07-25 | — | — | CN | claimed |
| EP-0991641-B1 | CRYSTALLINE FORM OF OMEPRAZOLE SODIUM SALT | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | EP | claimed |
| CN-1385214-A | Dissolvent specially for omeprazole sodium injection | CHEN QINGCAI (CN) | 2002-12-18 | — | — | CN | claimed |
| EP-1186602-A2 | Omeprazole sodium salt and its use as anti-ulcer agent | AstraZeneca AB (SE) | 2002-03-13 | — | — | EP | claimed |
| US-20010006649-A1 | STABLE ORAL PHARMACEUTICAL DOSAGE FORMS | SAGE PHARMACEUTICALS, INC. | 2001-07-05 | — | — | US | claimed |
| US-6207188-B1 | CRYSTALLIZATION OF OMEPRAZOLE WITH SODIUM HYDROXIDE IN AN ALCOHOL SOLUTION | ASTRAZENECA AB (SE) | 2001-03-27 | — | — | US | claimed |
| CN-1261362-A | Omeprazole sodium salt | ASTRA AB (SE) | 2000-07-26 | — | — | CN | claimed |
| EP-0991641-A1 | OMEPRAZOLE SODIUM SALT | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | claimed |
| WO-1999000380-A1 | OMEPRAZOLE SODIUM SALT | ASTRA AKTIEBOLAG (SE) | 1999-01-07 | — | — | WO | claimed |
| WO-1998050019-A1 | STABLE ORAL PHARMACEUTICAL DOSAGE FORMS | SAGE PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | claimed |
| CN-1136564-A | Omeprazole salt hydrate and preparation method thereof | CHANGZHOU PHARMACEUTICAL FACTO (CN) | 1996-11-27 | — | — | CN | claimed |