Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.41 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.38 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.38 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.38 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.38 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.38 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.38 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.38 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654434 | 0.93 | GCGR (0.45) | GCGRMCL1PPARD | |
| SCHEMBL2653760 | 0.90 | GCGR (0.50) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL13647269 | 0.90 | GCGR (0.44) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2654407 | 0.87 | GCGR (0.42) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2656490 | 0.86 | GCGR (0.41) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2653895 | 0.86 | GCGR (0.38) | GCGRPPARD | |
| SCHEMBL2656127 | 0.86 | GCGR (0.41) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2654428 | 0.85 | GCGR (0.44) | GCGRMCL1PPARD | |
| SCHEMBL2653286 | 0.85 | GCGR (0.42) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2654055 | 0.84 | GCGR (0.43) | GCGRADCY6ADCY3ADCY9ADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |