Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 6/20 | 0.46 |
| ▸ | GIPR | P48546 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661394 | 0.92 | MEN1 (0.48) | MEN1KMT2APPARAPPARDMAPK14 | |
| SCHEMBL2656186 | 0.90 | GCG (0.49) | MEN1KMT2AGCGRGIPRPPARA | |
| SCHEMBL2654727 | 0.89 | GCGR (0.55) | MEN1KMT2AGCGRGIPREPHX2 | |
| SCHEMBL2656558 | 0.87 | GCGR (0.45) | GCGRGIPRPPARAPPARD | |
| SCHEMBL2653326 | 0.87 | MEN1 (0.57) | MEN1KMT2AGCGRGIPRFFAR1 | |
| SCHEMBL2652593 | 0.87 | MEN1 (0.57) | MEN1KMT2AGCGRGIPRFFAR1 | |
| SCHEMBL2655721 | 0.86 | MEN1 (0.56) | MEN1KMT2AGCGRGIPRFFAR1 | |
| SCHEMBL2651906 | 0.86 | MEN1 (0.56) | MEN1KMT2AGCGRGIPRFFAR1 | |
| SCHEMBL2652886 | 0.85 | MEN1 (0.55) | MEN1KMT2AGCGRGIPRFFAR1 | |
| SCHEMBL2652235 | 0.85 | MEN1 (0.55) | MEN1KMT2AGCGRGIPRFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |