Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.51 |
| ▸ | GIPR | P48546 | 7/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653376 | 1.00 | GCGR (0.51) | GCGRGIPREPHX2EPHX1HDAC3 | |
| SCHEMBL2653469 | 0.89 | GCGR (0.53) | GCGRGIPREPHX2HDAC3HDAC11 | |
| SCHEMBL2653471 | 0.89 | GCGR (0.53) | GCGRGIPREPHX2HDAC3HDAC11 | |
| SCHEMBL2653500 | 0.88 | GCGR (0.66) | GCGRGIPREPHX2SERPINE1 | |
| SCHEMBL2653501 | 0.88 | GCGR (0.66) | GCGRGIPREPHX2SERPINE1 | |
| SCHEMBL2653817 | 0.87 | GCGR (0.51) | GCGRGIPREPHX2HDAC3HDAC11 | |
| SCHEMBL2653815 | 0.87 | GCGR (0.51) | GCGRGIPREPHX2HDAC3HDAC11 | |
| SCHEMBL2654197 | 0.86 | GCGR (0.53) | GCGRGIPREPHX2HDAC3HDAC11 | |
| SCHEMBL2654195 | 0.86 | GCGR (0.53) | GCGRGIPREPHX2HDAC3HDAC11 | |
| SCHEMBL2651592 | 0.86 | GCGR (0.52) | GCGRGIPREPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953812-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK, INC. (DK) | 2005-10-11 | — | — | US | claimed |
| WO-2004063147-A1 | SALTS AND SOLVATES OF GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2004-07-29 | — | — | WO | claimed |
| US-6562807-B2 | For prophylaxis and therapy of hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism, such as dyslipidemia, and obesity | NOVO NORDISK A/S (DK) | 2003-05-13 | — | — | US | claimed |
| US-6953812-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK, INC. (DK) | 2005-10-11 | — | — | US | disclosed |
| WO-2004063147-A1 | SALTS AND SOLVATES OF GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2004-07-29 | — | — | WO | disclosed |