Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 6/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655916 | 0.92 | PPARD (0.49) | PPARDMEN1KMT2AGCGRRARB | |
| SCHEMBL2655125 | 0.92 | GCGR (0.49) | GCGRRARBS1PR1FFAR1S1PR3 | |
| SCHEMBL2653706 | 0.91 | RARB (0.48) | MEN1KMT2AGCGRRARBS1PR1 | |
| SCHEMBL2653894 | 0.90 | FFAR1 (0.48) | PPARDMEN1KMT2AGCGRS1PR1 | |
| SCHEMBL2654924 | 0.90 | RARB (0.52) | PPARDMEN1KMT2AGCGRRARB | |
| SCHEMBL2653408 | 0.90 | RARB (0.49) | MEN1KMT2ARARBS1PR1FFAR1 | |
| SCHEMBL2656350 | 0.90 | PPARD (0.51) | PPARDGCGRFFAR1FFAR4PPARG | |
| SCHEMBL2654468 | 0.90 | PPARD (0.51) | PPARDMEN1KMT2AGCGRS1PR1 | |
| SCHEMBL2654850 | 0.89 | GCGR (0.53) | PPARDMEN1KMT2AGCGRS1PR1 | |
| SCHEMBL2661613 | 0.88 | MEN1 (0.55) | MEN1KMT2AGCGRS1PR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |