Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.50 |
| ▸ | JAK1 | P23458 | 10/20 | 0.50 |
| ▸ | JAK2 | O60674 | 9/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985302 | 0.92 | TYK2 (0.43) | TYK2JAK1JAK2PDE4DGRM5 | |
| SCHEMBL15713530 | 0.86 | TYK2 (0.65) | TYK2JAK1JAK2PDE4DKCNH2 | |
| SCHEMBL22647471 | 0.84 | JAK2 (0.47) | TYK2JAK1JAK2PDE4DGRM5 | |
| SCHEMBL15713772 | 0.82 | TYK2 (0.49) | TYK2JAK1JAK2PDE4DGRM5 | |
| SCHEMBL30940521 | 0.82 | GRM5 (0.43) | TYK2JAK1JAK2PDE4DGRM5 | |
| SCHEMBL20985236 | 0.82 | GRM5 (0.43) | TYK2JAK1JAK2PDE4DGRM5 | |
| SCHEMBL15713899 | 0.78 | TYK2 (0.48) | TYK2JAK1JAK2PDE4DKCNH2 | |
| SCHEMBL15713447 | 0.76 | TYK2 (0.49) | TYK2JAK1JAK2PDE4DPDE4B | |
| SCHEMBL15689504 | 0.76 | TYK2 (0.48) | TYK2JAK1JAK2PDE4DKCNH2 | |
| SCHEMBL26101076 | 0.75 | TYK2 (0.61) | TYK2JAK1JAK2PDE4DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787779-B2 | Sulfone pyridine alkyl amide-substituted heteroaryl compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787779-B2 | Sulfone pyridine alkyl amide-substituted heteroaryl compounds | TYK2, JAK3, JAK2 | TYK2 1/4885JAK1 4/4885JAK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.