Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.51 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 6/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085692 | 1.00 | GCK (0.51) | GCKACACBGRM5P2RX3P2RX2 | |
| SCHEMBL2086278 | 0.87 | GCK (0.40) | GCKACACBGRM5 | |
| SCHEMBL9987558 | 0.81 | GCK (0.75) | GCKACACBGRM5 | |
| SCHEMBL2085473 | 0.79 | GCK (0.56) | GCK | |
| SCHEMBL2086577 | 0.78 | GCK (0.40) | GCKGRM5P2RX3P2RX2 | |
| SCHEMBL2086026 | 0.78 | GCK (0.44) | GCK | |
| SCHEMBL12777889 | 0.78 | GCK (0.67) | GCK | |
| SCHEMBL2087690 | 0.78 | GCK (0.67) | GCK | |
| SCHEMBL2087705 | 0.73 | PRMT5 (0.39) | GCK | |
| SCHEMBL9987471 | 0.71 | GCK (0.74) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891069-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B]PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006125958-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |