Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | EGFR | P00533 | 6/20 | 0.57 |
| ▸ | BRAF | P15056 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 5/20 | 0.57 |
| ▸ | MET | P08581 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
| ▸ | TTK | P33981 | 1/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30393137 | 1.00 | EPHX2 (0.61) | EPHX2KDREGFRBRAFAURKA | |
| SCHEMBL26136652 | 0.94 | KDR (0.60) | EPHX2KDRAURKAMETAURKB | |
| SCHEMBL31137798 | 0.93 | AURKA (0.57) | EPHX2KDREGFRAURKAAURKB | |
| SCHEMBL26135146 | 0.93 | AURKA (0.57) | EPHX2KDREGFRAURKAAURKB | |
| SCHEMBL26135569 | 0.93 | AURKA (0.57) | EPHX2KDREGFRAURKAAURKB | |
| SCHEMBL30891768 | 0.91 | EPHX2 (0.51) | EPHX2KDREGFRBRAFAURKA | |
| SCHEMBL30891795 | 0.91 | KDR (0.54) | EPHX2KDREGFRAURKAMET | |
| SCHEMBL30393995 | 0.91 | AURKA (0.54) | EPHX2KDREGFRBRAFAURKA | |
| SCHEMBL26136636 | 0.91 | KDR (0.54) | EPHX2KDREGFRAURKAMET | |
| SCHEMBL26135202 | 0.91 | KDR (0.54) | EPHX2KDREGFRAURKAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201909-A | Quinazoline derivative compound and use thereof | 株式会社沃若诺伊 | 2024-06-14 | — | — | CN | claimed |
| WO-2023075529-A1 | QUINAZOLINE DERIVATIVE COMPOUND AND USE THEREOF | 보로노이바이오 주식회사 | 2023-05-04 | — | — | WO | disclosed |