Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.72 |
| ▸ | RARA | P10276 | 3/20 | 0.55 |
| ▸ | RARB | P10826 | 3/20 | 0.55 |
| ▸ | RARG | P13631 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652506 | 0.94 | GCK (0.81) | GCKRARARARBRARGMEN1 | |
| SCHEMBL5430262 | 0.89 | GCK (0.72) | GCKRARARARBRARGMEN1 | |
| SCHEMBL2651714 | 0.87 | GCK (0.85) | GCKRARARARBRARG | |
| SCHEMBL14505831 | 0.87 | GCK (0.70) | GCKRARARARBRARGMEN1 | |
| SCHEMBL2653357 | 0.86 | NPC1 (0.56) | GCKRARARARBRARGNPC1 | |
| SCHEMBL2655428 | 0.86 | GCK (0.75) | GCKRARARARBRARG | |
| SCHEMBL2654489 | 0.86 | GCK (0.75) | GCKRARARARBRARG | |
| SCHEMBL5430637 | 0.85 | GCK (0.73) | GCKRARARARBRARG | |
| SCHEMBL2655429 | 0.85 | GCK (0.70) | GCKRARARARBRARG | |
| SCHEMBL2655968 | 0.85 | GCK (0.67) | GCKRARARARBRARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697325-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056530-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2005-06-23 | — | — | WO | disclosed |