Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 1.00 |
| ▸ | RARA | P10276 | 2/20 | 0.78 |
| ▸ | RARB | P10826 | 2/20 | 0.78 |
| ▸ | RARG | P13631 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5439579 | 1.00 | GCK (1.00) | GCKRARARARBRARG | |
| SCHEMBL14520614 | 0.94 | GCK (0.88) | GCKRARARARBRARG | |
| SCHEMBL14520615 | 0.94 | GCK (0.88) | GCKRARARARBRARG | |
| SCHEMBL13044582 | 0.91 | GCK (0.83) | GCKRARARARBRARG | |
| SCHEMBL361534 | 0.91 | GCK (0.83) | GCKRARARARBRARG | |
| SCHEMBL7935638 | 0.91 | GCK (0.83) | GCKRARARARBRARG | |
| SCHEMBL14366894 | 0.88 | GCK (1.00) | GCKRARARARBRARG | |
| SCHEMBL29434815 | 0.88 | GCK (1.00) | GCKRARARARBRARG | |
| SCHEMBL29433060 | 0.88 | GCK (1.00) | GCKRARARARBRARG | |
| SCHEMBL2667703 | 0.88 | GCK (1.00) | GCKRARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078168-A1 | PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2007-04-05 | — | — | US | claimed |
| EP-1682509-A1 | PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | claimed |
| WO-2005044801-A1 | PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2005-05-19 | — | — | WO | claimed |
| US-20070078168-A1 | PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078168-A1 | PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS | GCK, GCKR, GALK1 | GCK 1/4885RARA 2455/4885RARB 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.