Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | ESRRG | P62508 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.49 |
| ▸ | ESRRB | O95718 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654356 | 1.00 | NPC1 (0.53) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2655081 | 0.99 | NPC1 (0.54) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2655436 | 0.96 | NPC1 (0.55) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2656353 | 0.93 | ESRRG (0.55) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2653990 | 0.91 | MEN1 (0.56) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2654466 | 0.91 | MEN1 (0.56) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2655220 | 0.91 | NPC1 (0.57) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2655124 | 0.91 | NPC1 (0.57) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2656581 | 0.91 | NPC1 (0.57) | NPC1RAB9AESRRGPOLBCASP3 | |
| SCHEMBL2653250 | 0.90 | MEN1 (0.57) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |