Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653067 | 0.90 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2653673 | 0.89 | HDAC3 (0.50) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2653395 | 0.88 | POLB (0.49) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2655129 | 0.88 | POLB (0.49) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2654064 | 0.88 | POLB (0.49) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2653117 | 0.86 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL5736276 | 0.85 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL12838390 | 0.84 | HDAC3 (0.58) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL1889333 | 0.84 | TDP1 (0.51) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL1368290 | 0.83 | NPSR1 (0.50) | ALDH1A1CYP4F2CYP4A11TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |