Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.37 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.37 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.37 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652221 | 0.99 | GCGR (0.50) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL2654052 | 0.96 | GCGR (0.51) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL2652629 | 0.94 | GCGR (0.51) | GCGRACKR3POLBNPC1CASP3 | |
| SCHEMBL2654307 | 0.92 | HPGD (0.43) | GCGRACKR3ALDH1A1POLBNPC1 | |
| SCHEMBL2652586 | 0.92 | GCGR (0.45) | GCGRALDH1A1LMNAPRNPRECQL | |
| SCHEMBL2652386 | 0.91 | GCGR (0.42) | GCGRACKR3POLBNPC1CASP3 | |
| SCHEMBL2652620 | 0.91 | GCGR (0.46) | GCGRMCL1PPARGPPARDPPARA | |
| SCHEMBL2656127 | 0.90 | GCGR (0.41) | GCGRACKR3ALDH1A1LMNAPRNP | |
| SCHEMBL2656490 | 0.89 | GCGR (0.41) | GCGRACKR3POLBNPC1CASP3 | |
| SCHEMBL2652922 | 0.89 | GCGR (0.46) | GCGRMCL1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |