Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180748 | 0.88 | MEN1 (0.51) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL27743197 | 0.88 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1PDE10A | |
| Hydrochloric Acid SCHEMBL261736 | 0.88 | MEN1 (0.52) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL262164 | 0.86 | MEN1 (0.52) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL4161753 | 0.85 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL261724 | 0.84 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL262929 | 0.84 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL266815 | 0.84 | MEN1 (0.54) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL261998 | 0.84 | GAA (0.54) | MEN1GAAKMT2AFOXO1PDE10A | |
| SCHEMBL4165494 | 0.84 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629126-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC. (JP) | 2014-01-14 | — | — | US | disclosed |
| US-20120136025-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2012-05-31 | — | — | US | disclosed |
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20090197834-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136025-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | P2RY10, P2RY12, P2RY11 | MEN1 3327/4885GAA 4203/4885KMT2A 2966/4885 |
| US-20090197834-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | P2RY12, P2RY11, P2RY10 | MEN1 2994/4885GAA 4528/4885KMT2A 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.