Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 16/20 | 0.57 |
| ▸ | GIPR | P48546 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.50 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.50 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.50 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.50 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.50 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.50 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.50 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.50 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655109 | 1.00 | GCGR (0.57) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2652235 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2653574 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2654583 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2654985 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2661613 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2653662 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2652886 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2654122 | 0.91 | MEN1 (0.55) | GCGRGIPRS1PR1S1PR3S1PR5 | |
| SCHEMBL2653745 | 0.90 | GCGR (0.49) | GCGRTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |