Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656088 | 0.93 | S1PR1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2654583 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2661613 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2652235 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2653574 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2653662 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2654122 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2654985 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2652886 | 0.89 | MEN1 (0.55) | S1PR1S1PR3S1PR5RAB9ANPC1 | |
| SCHEMBL2662580 | 0.89 | S1PR1 (0.56) | S1PR1S1PR3S1PR5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |