SCHEMBL2654705 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	CCNB2	O95067	2/20	0.51

▸	CCNE2	O96020	2/20	0.51

▸	CDK1	P06493	2/20	0.51

▸	CDK4	P11802	2/20	0.51

▸	CCNB1	P14635	2/20	0.51

▸	CCND1	P24385	2/20	0.51

▸	CCNE1	P24864	2/20	0.51

▸	CDK2	P24941	2/20	0.51

▸	CCNB3	Q8WWL7	2/20	0.51

▸	GCK	P35557	17/20	0.46

▸	KCNH2	Q12809	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL883974	0.89	GCK (0.59)	CCNB2CCNE2CDK1CDK4CCNB1
SCHEMBL884075	0.89	GCK (0.59)	CCNB2CCNE2CDK1CDK4CCNB1
SCHEMBL886779	0.82	GCK (0.57)	GCK
SCHEMBL886778	0.82	GCK (0.57)	GCK
SCHEMBL885426	0.78	GCK (0.63)	GCK
SCHEMBL886788	0.78	GCK (0.63)	GCK
SCHEMBL884002	0.78	GCK (0.59)	GCK
SCHEMBL884001	0.78	GCK (0.59)	GCK
SCHEMBL883884	0.76	GCK (0.55)	GCK
SCHEMBL883882	0.76	GCK (0.55)	GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1824835-A1	HETEROAROMATIC GLUCOKINASE ACTIVATORS	NOVO NORDISK A/S (DK)	2007-08-29	—	—	EP	disclosed
WO-2006058923-A1	HETEROAROMATIC GLUCOKINASE ACTIVATORS	NOVO NORDISK A/S (DK)	2006-06-08	—	—	WO	disclosed