Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581747 | 1.00 | GCK (0.60) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL1582235 | 0.99 | GCK (0.58) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL9892936 | 0.89 | GCK (0.60) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL2666200 | 0.88 | GCK (0.59) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL1581861 | 0.86 | GCK (0.57) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL9072639 | 0.86 | GCK (0.57) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL1107322 | 0.86 | GCK (0.57) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL1581698 | 0.86 | GCK (0.60) | GCKCNR2KMT2AEPHX2PTGS2 | |
| SCHEMBL1581983 | 0.86 | GCK (0.49) | GCKKMT2APTGS2MEN1SMN1; SMN2 | |
| SCHEMBL1582297 | 0.86 | GCK (0.47) | GCKCNR2KMT2AEPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |