Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 4/20 | 0.45 |
| ▸ | GCGR | P47871 | 10/20 | 0.41 |
| ▸ | GIPR | P48546 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656922 | 0.88 | GCGR (0.49) | GCGGCGRGIPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL2654806 | 0.86 | GCGR (0.49) | GCGGCGRGIPRSMN1; SMN2NPC1 | |
| SCHEMBL2653970 | 0.85 | GCGR (0.49) | GCGGCGRGIPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL2655144 | 0.84 | GCGR (0.49) | GCGGCGRSMN1; SMN2MAPTNPC1 | |
| SCHEMBL2655131 | 0.84 | GCG (0.44) | GCGGCGRGIPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL2654589 | 0.83 | GCGR (0.48) | GCGRGIPRPPARD | |
| SCHEMBL2653405 | 0.83 | GCGR (0.53) | GCGGCGRGIPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL2654012 | 0.83 | GCGR (0.49) | GCGRGIPRNPC1RAB9A | |
| SCHEMBL2653538 | 0.82 | GCGR (0.51) | GCGGCGRGIPRVIPR2 | |
| SCHEMBL2657098 | 0.82 | GCGR (0.49) | GCGGCGRGIPRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |