Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654902 | 1.00 | MAPT (0.49) | MAPTMAPK1TDP1HTTKDM4E | |
| SCHEMBL2970798 | 0.86 | MAPT (0.55) | MAPTMAPK1TDP1KDM4EGAA | |
| SCHEMBL2970799 | 0.86 | MAPT (0.55) | MAPTMAPK1TDP1KDM4EGAA | |
| SCHEMBL15563477 | 0.81 | GAA (0.54) | MAPTTDP1HTTGAAALDH1A1 | |
| SCHEMBL15563478 | 0.81 | GAA (0.54) | MAPTTDP1HTTGAAALDH1A1 | |
| SCHEMBL3483129 | 0.80 | KMT2A (0.56) | MAPTMAPK1HTTLMNAALDH1A1 | |
| SCHEMBL22398238 | 0.80 | MAPT (0.51) | MAPTMAPK1TDP1HTTKDM4E | |
| SCHEMBL22398236 | 0.80 | MAPT (0.51) | MAPTMAPK1TDP1HTTKDM4E | |
| SCHEMBL27597146 | 0.79 | DHODH (0.53) | MAPTMAPK1HTTGAAALDH1A1 | |
| SCHEMBL4301761 | 0.79 | MAPT (0.69) | MAPTMAPK1TDP1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |