Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 14/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667078 | 0.85 | NPC1 (0.66) | NPC1RAB9AHPGDSGCKKCNH2 | |
| SCHEMBL1427233 | 0.83 | GCK (0.63) | NPC1RAB9AGCKKCNH2 | |
| SCHEMBL1427423 | 0.81 | GCK (0.54) | NPC1RAB9AGCKKCNH2 | |
| SCHEMBL2901755 | 0.81 | GCK (0.69) | GCKKCNH2 | |
| SCHEMBL2667095 | 0.81 | GCK (0.54) | NPC1RAB9AGCKKCNH2 | |
| SCHEMBL1427114 | 0.81 | GCK (0.54) | NPC1RAB9AGCKKCNH2 | |
| SCHEMBL3342969 | 0.81 | GCK (0.54) | NPC1RAB9AGCKKCNH2 | |
| SCHEMBL2899089 | 0.81 | GCK (0.69) | GCKKCNH2 | |
| SCHEMBL1426856 | 0.80 | GCK (0.58) | NPC1RAB9AHPGDSGCKKCNH2 | |
| SCHEMBL2290746 | 0.80 | GCK (0.60) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756076-A1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005121110-A1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-22 | — | — | WO | disclosed |