Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.49 |
| ▸ | GCG | P01275 | 3/20 | 0.40 |
| ▸ | GIPR | P48546 | 3/20 | 0.39 |
| ▸ | GLP1R | P43220 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765825 | 0.93 | GCGR (0.58) | GCGRGCGGIPRGLP1RCHRM5 | |
| SCHEMBL1765913 | 0.86 | GCGR (0.50) | GCGRGCGGIPR | |
| SCHEMBL1765085 | 0.85 | GCGR (0.62) | GCGRGCGGIPRGLP1R | |
| SCHEMBL1765759 | 0.85 | GCGR (0.54) | GCGR | |
| SCHEMBL1765108 | 0.82 | GCGR (0.51) | GCGRGCG | |
| SCHEMBL1765320 | 0.82 | GCGR (0.48) | GCGRGCGGIPRGLP1R | |
| SCHEMBL1765317 | 0.82 | GCGR (0.48) | GCGRGCGGIPRGLP1R | |
| SCHEMBL1765627 | 0.81 | GCGR (0.61) | GCGRGCGGIPRGLP1RCHRM5 | |
| SCHEMBL1765514 | 0.79 | GCGR (0.59) | GCGRGCGGIPRGLP1R | |
| SCHEMBL1765799 | 0.79 | GCGR (0.54) | GCGRGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |