Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657448 | 0.91 | GCK (0.58) | GCKADORA2APOLBALDH1A1MAPT | |
| SCHEMBL2657284 | 0.87 | GCK (0.89) | GCKADORA2APOLBADORA3ADORA2B | |
| SCHEMBL2656632 | 0.82 | GCK (1.00) | GCKADORA2APOLBADORA3ADORA2B | |
| SCHEMBL2655680 | 0.81 | GCK (0.60) | GCKPOLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2657222 | 0.80 | GCK (0.71) | GCKADORA2APOLBADORA3ADORA2B | |
| SCHEMBL10200351 | 0.77 | GCK (0.62) | GCKADORA2APOLBCNR1ADORA3 | |
| SCHEMBL2656277 | 0.76 | GCK (0.71) | GCKADORA2APOLBADORA3ADORA2B | |
| SCHEMBL2657563 | 0.76 | GCK (0.67) | GCKADORA2APOLBADORA3ALDH1A1 | |
| SCHEMBL2655646 | 0.75 | GCK (0.54) | GCKADORA2APOLBADORA3ADORA2B | |
| SCHEMBL2655826 | 0.74 | GCK (0.82) | GCKADORA2APOLBCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-A2 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | Advinus Therapeutics Private Limited (IN) | 2009-12-02 | — | — | EP | claimed |
| WO-2008104994-A2 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2008-09-04 | — | — | WO | claimed |