Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25493009 | 0.84 | HRH4 (0.68) | HRH4LRRK2 | |
| SCHEMBL25769210 | 0.83 | CHEK1 (0.53) | HRH4CHEK1MAPK10 | |
| SCHEMBL25493007 | 0.82 | HRH4 (0.69) | HRH4CHEK1 | |
| SCHEMBL19699523 | 0.80 | MTOR (0.49) | CHEK1MAPK10 | |
| Hydrochloric Acid SCHEMBL4721451 | 0.79 | CHEK1 (0.49) | HRH4CHEK1MAPK10CDK2 | |
| SCHEMBL26572368 | 0.78 | PCSK9 (0.54) | LRRK2CSF1RPDGFRACDK4CCNA2 | |
| SCHEMBL19706560 | 0.77 | ADORA2A (0.59) | CHEK1KCNH2MAPK10 | |
| SCHEMBL807537 | 0.77 | CHEK1 (0.47) | CHEK1LRRK2CDK2 | |
| SCHEMBL25292457 | 0.75 | MTOR (0.53) | CHEK1MAPK10 | |
| SCHEMBL847015 | 0.75 | HRH4 (0.72) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |