Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 6/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26556273 | 0.91 | JAK2 (0.41) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL26559027 | 0.89 | ENPP1 (0.43) | JAK3PRKDCPDE3AENPP1 | |
| SCHEMBL26561312 | 0.85 | IRAK4 (0.45) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL21664351 | 0.85 | ENPP1 (0.47) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL21664293 | 0.85 | ENPP1 (0.47) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL30562936 | 0.85 | ENPP1 (0.47) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL26564201 | 0.85 | JAK2 (0.41) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL21664352 | 0.85 | ENPP1 (0.47) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL26563126 | 0.85 | JAK2 (0.39) | JAK2JAK3JAK1IRAK4PRKDC | |
| SCHEMBL21664270 | 0.84 | ENPP1 (0.47) | JAK2JAK3JAK1IRAK4PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |