Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 3/20 | 0.69 |
| ▸ | GCGR | P47871 | 15/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765663 | 0.88 | GCG (0.70) | GCGGCGRADCY6ADCY3ADCY9 | |
| SCHEMBL1765380 | 0.87 | GCG (0.69) | GCGGCGRADCY6ADCY3ADCY9 | |
| SCHEMBL1765434 | 0.85 | GCG (0.74) | GCGGCGR | |
| SCHEMBL1765697 | 0.84 | GCG (0.73) | GCGGCGR | |
| SCHEMBL1765584 | 0.84 | GCG (0.73) | GCGGCGR | |
| SCHEMBL1765196 | 0.84 | GCG (0.75) | GCGGCGRADCY6ADCY3ADCY9 | |
| SCHEMBL13013081 | 0.82 | GCG (0.73) | GCGGCGR | |
| SCHEMBL1765445 | 0.82 | GCG (1.00) | GCGGCGR | |
| SCHEMBL1765672 | 0.82 | GCG (0.67) | GCGGCGR | |
| SCHEMBL1765433 | 0.79 | GCG (0.58) | GCGGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |