Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | GCGR | P47871 | 12/20 | 0.40 |
| ▸ | GIPR | P48546 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | GCG | P01275 | 2/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GLP1R | P43220 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655143 | 0.94 | GCGR (0.40) | DGAT1GCGRGIPRGCGKMT2A | |
| SCHEMBL2653785 | 0.91 | PPARA (0.41) | GCGRGIPRPPARAPPARGPPARD | |
| SCHEMBL2666610 | 0.86 | GCGR (0.44) | DGAT1GCGRGIPRPPARAGCG | |
| SCHEMBL2654428 | 0.85 | GCGR (0.44) | GCGRPPARAPPARGPPARD | |
| SCHEMBL2654450 | 0.85 | GCGR (0.47) | GCGRGIPRPPARAGCGPPARG | |
| SCHEMBL2655151 | 0.83 | PPARA (0.39) | PPARAP2RY14PPARGPPARDKMT2A | |
| SCHEMBL2654631 | 0.82 | KMT2A (0.41) | GCGRGIPRPPARAPPARGPPARD | |
| SCHEMBL2656186 | 0.82 | GCG (0.49) | GCGRGIPRPPARAGCGKMT2A | |
| SCHEMBL13647261 | 0.79 | GCGR (0.48) | GCGRGIPRGCGKMT2AGLP1R | |
| SCHEMBL2653887 | 0.78 | PPARA (0.42) | GCGRGIPRPPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |