SCHEMBL2655795

SCHEMBL2655795

O=C(O)CCNC(=O)c1ccc(N(Cc2ccc(C3=CCCCC3)cc2)C(=O)Nc2cc(Cl)cc(Cl)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GCGR P47871 20/20 1.00
GIPR P48546 17/20 1.00
GLP1R P43220 4/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2652197 1.00 GCGR (1.00) GCGRGIPRGLP1R
SCHEMBL2650112 0.93 GCGR (0.86) GCGRGIPRGLP1R
SCHEMBL2665423 0.92 GCGR (0.84) GCGRGIPRGLP1R
SCHEMBL2651380 0.90 GCGR (0.82) GCGRGIPRGLP1R
SCHEMBL2663520 0.90 GCGR (0.81) GCGRGIPRGLP1R
SCHEMBL13800856 0.90 GCGR (0.81) GCGRGIPRGLP1R
SCHEMBL9072880 0.90 GCGR (0.81) GCGRGIPRGLP1R
SCHEMBL2654867 0.89 GCGR (0.79) GCGRGIPRGLP1R
SCHEMBL2652053 0.88 GCGR (0.79) GCGRGIPRGLP1R
SCHEMBL2665387 0.88 GCGR (0.78) GCGRGIPRGLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040152750-A1 Novel glucagon antagonists NOVO NORDISK A/S (DK) 2004-08-05 US disclosed
WO-2004056763-A2 NOVEL GLUCAGON ANTAGONISTS NOVO NORDISK A/S (DK) 2004-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040152750-A1 Novel glucagon antagonists GLP1R, GCGR, GIPR GCGR 2/4885GIPR 3/4885GLP1R 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.