SCHEMBL2656083

SCHEMBL2656083

O=C(O)CCNC(=O)c1ccc(N(Cc2ccc(C3CCCCC3)cc2)C(=O)Oc2cccc(-c3ccccc3)c2)cc1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GCGR P47871 13/20 0.59
STAT3 P40763 4/20 0.50
GIPR P48546 9/20 0.47
GLP1R P43220 2/20 0.43
OPRM1 P35372 1/20 0.42
OPRK1 P41145 1/20 0.42
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2653454 0.93 GCGR (0.63) GCGRSTAT3GIPRGLP1ROPRM1
SCHEMBL13800141 0.88 GCGR (0.65) GCGRSTAT3GIPRGLP1ROPRM1
SCHEMBL4095401 0.88 GCGR (0.71) GCGRSTAT3GIPRGLP1R
SCHEMBL2652974 0.88 GCGR (0.71) GCGRSTAT3GIPRGLP1R
SCHEMBL2663319 0.88 GCGR (0.75) GCGRSTAT3GIPRGLP1ROPRM1
SCHEMBL2653450 0.87 GCGR (0.52) GCGRSTAT3GIPROPRM1OPRK1
SCHEMBL2662082 0.86 GCGR (0.63) GCGRSTAT3GIPRGLP1R
SCHEMBL2663153 0.86 GCGR (0.60) GCGRSTAT3GIPRGLP1ROPRM1
SCHEMBL2666459 0.86 GCGR (0.64) GCGRSTAT3GIPRGLP1R
SCHEMBL2655207 0.86 GCGR (0.44) GCGRSTAT3GIPRGLP1ROPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040152750-A1 Novel glucagon antagonists NOVO NORDISK A/S (DK) 2004-08-05 US disclosed
WO-2004056763-A2 NOVEL GLUCAGON ANTAGONISTS NOVO NORDISK A/S (DK) 2004-07-08 WO disclosed
WO-2004056763-A2 NOVEL GLUCAGON ANTAGONISTS NOVO NORDISK A/S (DK) 2004-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040152750-A1 Novel glucagon antagonists GLP1R, GCGR, GIPR GCGR 2/4885STAT3 1711/4885GIPR 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.