SCHEMBL2656084

SCHEMBL2656084

CCOC(=O)Cc1nc(NC(=O)C(Oc2ccc(Cl)cc2)c2ccc(S(=O)(=O)C3CC3)cc2)sc1Cl

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 19/20 0.52
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3767955 0.95 GCK (0.46) GCK
SCHEMBL3766343 0.94 GCK (0.48) GCK
SCHEMBL2657190 0.92 GCK (0.47) GCK
SCHEMBL2658480 0.92 GCK (0.48) GCK
SCHEMBL3767938 0.89 GCK (0.58) GCK
SCHEMBL2660415 0.88 GCK (0.44) GCK
SCHEMBL3768425 0.88 GCK (0.55) GCK
SCHEMBL2656694 0.87 GCK (0.46) GCK
SCHEMBL624737 0.86 GCK (0.57) GCK
SCHEMBL3761360 0.86 GCK (0.54) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2195304-B1 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2014-01-08 EP claimed
US-8501955-B2 Acetamide derivatives as glucokinase activators, their process and medicinal application ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2013-08-06 US claimed
EP-2195304-A2 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS Advinus Therapeutics Private Limited (IN) 2010-06-16 EP claimed
WO-2009047798-A2 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2009-04-16 WO claimed