Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656038 | 0.79 | GCK (0.38) | GCK | |
| SCHEMBL1629163 | 0.70 | USP8 (0.38) | — | |
| SCHEMBL2655729 | 0.68 | SLC22A12 (0.42) | GCK | |
| SCHEMBL2661045 | 0.68 | CHEK1 (0.37) | — | |
| SCHEMBL2656458 | 0.67 | GAA (0.32) | — | |
| SCHEMBL1329646 | 0.65 | SLC22A12 (0.40) | — | |
| SCHEMBL2658113 | 0.65 | S1PR4 (0.38) | GCK | |
| SCHEMBL20944147 | 0.65 | GRM5 (0.42) | — | |
| SCHEMBL3593503 | 0.64 | BRD4 (0.34) | — | |
| SCHEMBL28573574 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209778-A1 | PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | Array Biopharma, Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009042435-A1 | PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | ARRAY BIOPHARMA INC. (US) | 2009-04-02 | — | — | WO | disclosed |