Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644375 | 0.91 | GCK (0.69) | GCKNPC1RAB9AMITFTP53 | |
| SCHEMBL2662557 | 0.87 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL643624 | 0.84 | GCK (0.56) | GCKNPC1RAB9AMITFTP53 | |
| SCHEMBL644806 | 0.82 | GCK (0.54) | GCKNPC1RAB9AKCNH2 | |
| SCHEMBL643664 | 0.80 | GCK (0.58) | GCKNPC1RAB9AMITFTP53 | |
| SCHEMBL643433 | 0.80 | GCK (0.52) | GCKNPC1RAB9AKCNH2TSHR | |
| SCHEMBL643599 | 0.80 | GCK (0.65) | GCKNPC1RAB9AMITFTP53 | |
| SCHEMBL645185 | 0.78 | GCK (0.68) | GCKKCNH2 | |
| SCHEMBL9923354 | 0.78 | GCK (0.51) | GCKNPC1RAB9AKCNH2 | |
| SCHEMBL645613 | 0.77 | GCK (0.61) | GCKNPC1RAB9AMITFTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010520-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | Pfizer Products Incorporated (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |