Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656128 | 0.85 | GCK (0.52) | GCKKCNH2HRH3ALDH1A1HPGD | |
| SCHEMBL1427066 | 0.84 | MEN1 (0.55) | GCKKCNH2HRH3ALDH1A1KMT2A | |
| SCHEMBL1427045 | 0.84 | GCK (0.60) | GCKKCNH2HRH3KMT2AMEN1 | |
| SCHEMBL2667109 | 0.84 | HRH3 (0.51) | GCKKCNH2HRH3DRD3SMN1; SMN2 | |
| SCHEMBL1427027 | 0.83 | GCK (0.73) | GCKKCNH2HRH3 | |
| SCHEMBL17934006 | 0.83 | GCK (0.73) | GCKKCNH2HRH3 | |
| SCHEMBL1427000 | 0.83 | GCK (0.61) | GCKKCNH2HRH3 | |
| SCHEMBL1492957 | 0.83 | GCK (0.58) | GCKKCNH2HRH3 | |
| SCHEMBL1380708 | 0.82 | GCK (0.61) | GCKKCNH2 | |
| SCHEMBL2075334 | 0.79 | HRH3 (0.48) | GCKKCNH2HRH3DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902052-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | AstraZeneca AB (SE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007007041-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |