Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.50 |
| ▸ | CPS1 | P31327 | 12/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2644328 | 0.88 | GCK (0.56) | GCKCPS1CCR1PARP1LRRK2 | |
| SCHEMBL2644322 | 0.88 | GCK (0.56) | GCKCPS1CCR1PARP1LRRK2 | |
| SCHEMBL2644380 | 0.88 | GCK (0.56) | GCKCPS1CCR1PARP1LRRK2 | |
| SCHEMBL644916 | 0.81 | GCK (0.80) | GCKCPS1 | |
| SCHEMBL643799 | 0.81 | GCK (0.80) | GCKCPS1 | |
| SCHEMBL9923383 | 0.80 | GCK (0.53) | GCKCPS1CCR1PARP1LRRK2 | |
| SCHEMBL2644034 | 0.79 | GCK (0.58) | GCKCPS1 | |
| SCHEMBL2644060 | 0.79 | GCK (0.58) | GCKCPS1 | |
| SCHEMBL2644031 | 0.79 | GCK (0.58) | GCKCPS1 | |
| SCHEMBL2643379 | 0.78 | GCK (0.57) | GCKCPS1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010520-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | Pfizer Products Incorporated (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |