Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2074279 | 1.00 | GCK (0.48) | GCKHRH1HRH3SCN9AHPGDS | |
| SCHEMBL2075157 | 0.91 | GCK (0.49) | GCKHRH1HRH3SCN9A | |
| SCHEMBL2669545 | 0.90 | GCK (0.49) | GCKHRH1HRH3SCN9A | |
| SCHEMBL2669552 | 0.90 | GCK (0.49) | GCKHRH1HRH3SCN9A | |
| SCHEMBL2074604 | 0.86 | GCK (0.47) | GCKHRH1HRH3 | |
| SCHEMBL2074947 | 0.86 | GCK (0.47) | GCKHRH1HRH3 | |
| SCHEMBL2659316 | 0.85 | GCK (0.56) | GCK | |
| SCHEMBL2074639 | 0.85 | GCK (0.56) | GCK | |
| SCHEMBL2075590 | 0.82 | GCK (0.43) | GCKHRH1HRH3 | |
| SCHEMBL2074572 | 0.82 | GRM5 (0.43) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086964-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | Astra Zeneca AB (SE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008050101-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |