SCHEMBL2658059

SCHEMBL2658059

O=C(Nc1n[c]c(Cl)s1)C(Oc1ccc(F)cc1F)c1ccc(S(=O)(=O)C2CCCC2)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 19/20 0.51
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2658644 0.97 GCK (0.54) GCK
SCHEMBL2657345 0.90 GCK (0.61) GCK
SCHEMBL2657322 0.89 GCK (0.60) GCK
SCHEMBL2656750 0.88 GCK (0.49) GCKKCNH2
SCHEMBL2658051 0.87 GCK (0.59) GCK
SCHEMBL2658072 0.87 GCK (0.59) GCK
SCHEMBL2658315 0.86 GCK (0.65) GCK
SCHEMBL2656190 0.84 GCK (0.52) GCKKCNH2
SCHEMBL2656848 0.83 GCK (0.63) GCK
SCHEMBL2657184 0.83 GCK (0.48) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2195304-B1 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2014-01-08 EP claimed
EP-2195304-A2 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS Advinus Therapeutics Private Limited (IN) 2010-06-16 EP claimed
WO-2009047798-A2 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2009-04-16 WO claimed
EP-2195304-B1 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2014-01-08 EP disclosed