Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 20/20 | 0.63 |
| ▸ | GIPR | P48546 | 7/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252568 | 0.95 | GCGR (0.63) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2659488 | 0.86 | GCGR (0.76) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2660390 | 0.81 | GCGR (0.63) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2660216 | 0.80 | GCGR (0.56) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2660205 | 0.78 | GCGR (0.58) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL3383384 | 0.78 | GCGR (0.62) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL9071080 | 0.78 | GCGR (1.00) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667331 | 0.77 | GCGR (1.00) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13356671 | 0.77 | GCGR (0.63) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL3256741 | 0.77 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773330-A4 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | disclosed |
| EP-1773330-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014618-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |