Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ro-281675 SCHEMBL7089685 | 0.87 | GCK (1.00) | GCKKCNH2FFAR2 | |
| Ro-281675 SCHEMBL2646000 | 0.87 | GCK (1.00) | GCKKCNH2FFAR2 | |
| Ro-281675 SCHEMBL2645615 | 0.87 | GCK (1.00) | GCKKCNH2FFAR2 | |
| SCHEMBL2645004 | 0.86 | GCK (0.98) | GCKKCNH2FFAR2 | |
| SCHEMBL2645066 | 0.86 | GCK (0.98) | GCKKCNH2FFAR2 | |
| SCHEMBL2650222 | 0.85 | GCK (0.79) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2659048 | 0.85 | GCK (0.77) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2646496 | 0.84 | GCK (0.83) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2649427 | 0.84 | GCK (0.76) | GCKKCNH2FFAR2CYP1A2CYP3A4 | |
| SCHEMBL2644739 | 0.84 | GCK (0.76) | GCKKCNH2FFAR2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283830-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001085707-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | disclosed |