Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.51 |
| ▸ | THRA | P10827 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570437 | 0.97 | CYP4A11 (0.49) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL1561190 | 0.93 | CYP4A11 (0.46) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL2211024 | 0.90 | CA1 (0.46) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL8293510 | 0.87 | RARB (0.55) | CYP4A11CYP4F2THRATHRBRARB | |
| SCHEMBL1560634 | 0.87 | CYP4A11 (0.69) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL20046685 | 0.86 | CYP4A11 (0.67) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL8568072 | 0.86 | CYP4A11 (0.67) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL6209198 | 0.86 | CYP4A11 (0.50) | CYP4A11CYP4F2THRATHRBCA12 | |
| SCHEMBL7855043 | 0.85 | CYP4A11 (0.68) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL8997287 | 0.85 | CYP4A11 (0.54) | CYP4A11CYP4F2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010098994-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2010-09-02 | — | — | WO | disclosed |